RESEARCH

Veracity Clinical Research contributes to global knowledge

 

Veracity Clinical Research is fortunate to contribute to world literature in the field of dermatology. In the past year, we have had numerous poster presentations in a number of publications and presented at various conferences around the world. Posters include:

 

  •  ERASURE and FIXTURE study groups which were published in The New England Journal of Medicine

  •  Daylight PDT with methyl aminolevulinate published in The British Journal of Dermatology

  •  FIXTURE study group poster presented in Indiana USA in June

  •  Daylight PDT poster presented at Australasian Dermatology Nurses Association's 13th National Conference

  •  Poster presentation of Sukukimab presented at Winter Clinical Dermatology conference in Hawaii

 

Publications:

2021

Wu, J.J., Spelman, L., Tan, J.L. et al. (2021). Dupilumab Maintains Long-Term Disease Control in Adults with Moderate-to-Severe Atopic Dermatitis as Measured by Well-Controlled Weeks: Results from the LIBERTY AD CHRONOS Clinical Trial. Published in Dermatology and Therapy, 28 January 2021. https://doi.org/10.1007/s13555-021-00487-y

Sinclair, R., Baker, C., Spelman, L., Supranowicz, M. and MacMahon, B. (2021). A review of actinic keratosis, skin field cancerisation and the efficacy of topical therapies. Australasian Journal of Dermatology, 62: 119-123. https://doi.org/10.1111/ajd.13447

2020

Wollenberg, A., Blauvelt, A., Guttman-Yassky, E., Worm, M., Lynde, C., Lacour, J.P., Spelman, L., Katoh, N., Saeki, H., Poulin, Y., Lesiak, A., Kircik, L., Cho, S.H., Herranz, P., Cork, M.J., Peris, K., Steffensen, L.A., Bang, B., Kuznetsova, A., Jensen, T.N., Østerdal, M.L., Simpson, E.L. and on behalf of the ECZTRA 1 and ECZTRA 2 study investigators. (2020). Tralokinumab for moderate‐to‐severe atopic dermatitis: results from two 52‐week, randomized, double‐blind, multicentre, placebo‐controlled phase III trials (ECZTRA 1 and ECZTRA 2). https://doi.org/10.1111/bjd.19574

Spelman, L., Rubel, D., Brnabic, A., Burkhardt, N., Riedl, E. & Foley, P. (2020). A subset analysis of efficacy and safety outcomes from phase 3 clinical studies of ixekizumab for the treatment of patients with severe plaque psoriasis. Published in the Journal of Dermatological Treatment. https://doi.org/10.1080/09546634.2020.1752888

2018

Fogarty, G.B., Christie, D., Spelman, L.J., Supranowicz, M.J., Sinclair, R.J. (2018). Can Modern Radiotherapy be used for Extensive Skin Field Cancerisation: An Update on Current Treatment Options. Published in Biomedical Journal of Scientific and Technical Research. https://doi.org/10.26717/BJSTR.2018.04.000998 

Spelman, L. et al. (2018). An Investigator Blinded, Clinical Trial Assessing the Efficacy of Superfine Merino Wool Base Layer Garments (SMWBG) in Children with Atopic Dermatitis (AD) Measuring SCORAD1, EASI2, POEM3 and DSA4 Scores. Biomedical Journal of Scientific & Technical Research. https://doi.org/10.26717/BJSTR.2018.07.001450

 

2016

Spelman, L., Rubel, D., Murrell, D.F., See, J.-A., Hewitt, D., Foley, P., Salmon, R., Kerob, D., Pascual, T., Shumack, S. & Fernandez-Penas, P. (2016). DL-PDT possible all year in Australia. Australasian Journal of Dermatology, 57: 24-28. https://doi.org/10.1111/ajd.12295

Zane L.T., Chanda S., Jarnagin K., Nelson D.B., Spelman L. & Stein Gold L.F. (2016). Crisaborole and its potential role in treating atopic dermatitis: overview of early clinical studies. Immunotherapy VOL. 8, NO. 8. https://doi.org/10.2217/imt-2016-0023 

2015

Spelman, L., Su, J. C., Fernandez-Peñas, P., Varigos, G. A., Cooper, A. J., Baker, C. S., Lee, M., Ring, J. M., & Thirunavukkarasu, K. (2015). Frequency of undiagnosed psoriatic arthritis among psoriasis patients in Australian dermatology practice. Journal of the European Academy of Dermatology and Venereology: JEADV, 29(11), 2184–2191. https://doi.org/10.1111/jdv.13210

2014

Rubel, D.M., Spelman, L., Murrell, D.F., See, J.-A., Hewitt, D., Foley, P., Kerob, D., Kerrouche, N., Wulf, H.C., Shumack, S. (2014). Daylight PDT with methyl aminolevulinate cream as a convenient, similarly effective, nearly painless alternative to conventional PDT in actinic keratosis treatment: a randomized controlled trial. The British Journal of Dermatology, 171: 1164-1171. https://doi.org/10.1111/bjd.13138 

 

2013

Rowe, C., Spelman, L., Oziemski, M., Ryan, A., Manoharan, S., Wilson, P., Daubney, M. and Scott, J. (2013). Isotretinoin and mental health in adolescents: Australian consensus. Published in Australasian Journal of Dermatology, 28 November 2013. https://doi.org/10.1111/ajd.12117

 

2008

Kaufmann, R., Spelman, L., Weightman, W., Reifenberger, J., Szeimies, R.M., Verhaeghe, E., Kerrouche, N., Sorba, V., Villemagne, H. and Rhodes, L.E. (2008). Multicentre intraindividual randomized trial of topical methyl aminolaevulinate-photodynamic therapy vs. cryotherapy for multiple actinic keratoses on the extremities. The British journal of dermatology, 158(5), 994–999. https://doi.org/10.1111/j.1365-2133.2008.08488.x

 

2006

Hofman, T., Cranswick, N., Kuna, P., Boznanski, A., Latos, T., Gold, M., Murrell, D.F., Gebauer, K., Behre, U., Machura, E., Olafsson, J., Szalai, Z. on behalf of the International Tacrolimus Ointment Study Group. Tacrolimus ointment does not affect the immediate response to vaccination, the generation of immune memory, or humoral and cell-mediated immunity in children. Archives of Disease in Childhood 2006;91:905-910. https://doi.org/10.1136/adc.2006.094276

 

2005

Vinciullo, C., Elliott, T., Francis, D., Gebauer, K., Spelman, L., Nguyen, R., Weightman, W., Sheridan, A., Reid, C., Czarnecki, D., & Murrell, D. (2005). Photodynamic therapy with topical methyl aminolaevulinate for 'difficult-to-treat' basal cell carcinoma. The British journal of dermatology, 152(4), 765–772. https://doi.org/10.1111/j.1365-2133.2005.06484.x

 

2004

Thai, K. E., Fergin, P., Freeman, M., Vinciullo, C., Francis, D., Spelman, L., Murrell, D., Anderson, C., Weightman, W., Reid, C., Watson, A., & Foley, P. (2004). A prospective study of the use of cryosurgery for the treatment of actinic keratoses. International Journal of Dermatology, 43(9), 687–692. https://doi.org/10.1111/j.1365-4632.2004.02056.x

 

Noakes, R. R., & Spelman, L. (2004). Köbnerization in a woman with generalized lichen sclerosus. The Australasian Journal of Dermatology, 45(2), 144–145. https://doi.org/10.1111/j.1440-0960.2004.00063.x

 

2003

Martinez-Mir, A., Glaser, B., Chuang, G. S., Horev, L., Waldman, A., Engler, D. E., Gordon, D., Spelman, L. J., Hatzibougias, I., Green, J., Christiano, A. M., & Zlotogorski, A. (2003). Germline fumarate hydratase mutations in families with multiple cutaneous and uterine leiomyomata. The Journal of Investigative Dermatology, 121(4), 741–744. https://doi.org/10.1046/j.1523-1747.2003.12499.x

 

Freeman, M., Vinciullo, C., Francis, D., Spelman, L., Nguyen, R., Fergin, P., Thai, K. E., Murrell, D., Weightman, W., Anderson, C., Reid, C., Watson, A., & Foley, P. (2003). A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study. The Journal of Dermatological Treatment, 14(2), 99–106. https://doi.org/10.1080/09546630310012118  

 

2001

Spelman, L., & Dicker, T. (2001). Aquagenic pruritus relieved by tight fitting clothing. The Australasian Journal of Dermatology, 42(2), 146.

 

 

Posters/Abstracts/Oral Presentations:

2021

Blauvelt, A., Wollenberg, A., Pink, A., Worm, M., Peris, K., Armstrong, A., Spelman, L., Saeki, H., Lynde, C., Thyssen, J.P., Herranz, P., Barbarot, S., Abildgaard Steffensen, L., Kuznetsova, A., & Simpson, E. (2021). Assessing Long-term Maintenance of Efficacy With Tralokinumab Monotherapy in Patients With Moderate-to-severe Atopic Dermatitis: Combined Results From Two Phase 3, Randomized, Double-blind, Placebo-controlled Trials (ECZTRA 1 and 2). [Poster Link] American Academy of Dermatology Association Virtual Meeting Experience (AAD VMX), April 23−25, 2021.

 

2020

Wang, J., White, J., Sansone, K., Spelman, L., Sinclair, R., Yang, S., Pan, W., Wei, Z., Connect Biopharma, San Diego, CA, USA and Suzhou, China; Veracity Clinical Research Pty Ltd. Woolloongabba, Queensland, Australia; Sinclair Dermatology, East Melbourne, Australia. (2020). A randomized, double-blind, placebo-controlled, multiple ascending dose study of the safety, pharmacokinetics and preliminary efficacy of CBP-201 in adult patients with moderate to severe atopic dermatitis (CBP-201AU002) [Poster Link] 29th EADV Congress, Vienna, 28th October - 1st November 2020.

Su J. C., Spelman L. J., Eichenfield L. F., Stein Gold L. F., Cha A., Graham D., Takiya L., Werth J. L., Zang C., Vlahos B. Efficacy and Safety of Crisaborole in Patients ≥3 Months of Age With Mild-to-Moderate Atopic Dermatitis (AD). [Poster Link] Presented at the Maui Derm Virtual Congress; June 24-27, 2020.

2017

Spelman, L. (2017). AWI002: Trials, tribulations and the value of persisting with non-drug related clinical trials – superfine merino wool base layer garments in atopic dermatitis. Presented at 3rd International Conference on Advanced Clinical Research and Clinical Trials, September 20-21, 2017 Dublin, Ireland. Abstract Link.

Spelman, L. (2017). Assessing safety and tolerability of Volumetric-Modulated Arc Therapy (VMAT) or RapidArc radiation therapy for the treatment of skin cancers and inflammatory skin conditions. Presented at 17th World Dermatology Congress, September 25-26, 2017 Dubai, UAE. Abstract Link.

 

2014

Langley R, Reich K, Griffiths C, Puig L, Spelman L, Rivas Zaldivar E, Wasel N, Salko T, Notter M, Helou S, Papavassilis C; for the FIXTURE Study Group. Secukinumab compared with placebo and etanercept in moderate-to-severe plaque psoriasis: a head-to-head comparison of 2 biologics in FIXTURE phase 3 study. [Poster] Society of Dermatology Physician Assistants Annual Summer Dermatology Conference, Indianapolis, Indiana, USA, May-Jun 2014.

 

Spelman L, Holland T, Davidson K. Best Practice Guidelines for Daylight Photodynamic Therapy (DL-PDT). [Poster] The Australian Dermatology Nurses Association 13th National Conference, Melbourne, Victoria, May 2014.

 

Langley R, Reich K, Griffiths C, Puig L, Spelman L, Rivas Zaldivar E, Wasel N, Salko T, Notter M, Helou S, Papavassilis. Secukinumab compared with placebo and etanercept: a head-to-head comparison of 2 biologics in a phase 3 study of moderate-to-severe plaque psoriasis (FIXTURE). [Poster] 10th Annual Maui Derm Conference, Maui, Hawaii, Jan 2014

 

Langley R, Reich K, Griffiths C, Puig L, Spelman L, Rivas Zaldivar E, Wasel N, Salko T, Notter M, Helou S, Papavassilis. Secukinumab compared with placebo and etanercept: a head-to-head comparison of 2 biologics in a phase 3 study of moderate-to-severe plaque psoriasis (FIXTURE). [Poster] 2014 Winter Clinical Dermatology Conference, Kona Coast, Hawaii, Jan 2014.

 

2013

Stein-Gold L, Spelman L, Spellman MC, Hughes M, Zane LT. Safety and efficacy of AN2728 topical ointment, 2% and 0.5%, in a phase 2 dose-ranging study of adolescents with mild-to-moderate atopic dermatitis. [Poster] 2013 Australasian College of Dermatologists Biennial Spring Meeting, Cairns, Queensland, Oct 2013.

 

Langley R, Reich K, Griffiths C, Puig L, Spelman L, Rivas Zaldivar E, Wasel N, Salko T, Notter M, Helou S, Papavassilis C. Secukinumab compared with placebo and etanercept: The first 52-week head-to-head comparison of two biologics in a randomized, double-blind phase 3 study in subjects with moderate-to-severe psoriasis (FIXTURE). [Abstract] 22nd Congress of the EADV, Istanbul, Turkey, Oct 2013.

 

Spelman, L. Daylight PDT: a convenient, similarly effective, and nearly painless alternative to conventional PDT. [Oral Presentation] Dermatology Update 2013, Montreal, Quebec, Canada

 

2008

Freeman M, Oakley A, Siller G, Rosen R, Salmon P, Spelman L, Shumack S, Rubel D, Birchall N, Katsamas J. Study to determine the optimal tolerated regimen of ingenol mebutate (PEP005) gel for actinic keratosis of the face or face and scalp. [Poster P2010] AAD Summer Meeting, Chicago, Illinois, USA, Jul/Aug 2008.

 

2007

Spelman L. Metvix in AK’s other than face and scalp. [Poster] 7th EURO-PDT Annual Congress, Paris, France, Mar 2007.